复合维生素不能减少老年女性患肿瘤、冠心病和死亡风险
来源：医心网 发布时间：2009-02-26 08:49
MedWire报道：复合维生素，这种最常用的膳食补充剂，对绝经期后的女性患肿瘤、心血管疾病或死亡率风险没有影响，该结果是根据一项大型研究发现的。
研究使用了女性健康研究中161，808例志愿者的数据，将其中68，132例随机分配到干预组（激素治疗，调整饮食和补充钙/维生素D），93，676例分到对照组。
研究登记从1993年到1998年，随访中位期在干预组和对照组分别为8.0和7.9。总的复合维生素使用率为41.5%。
美国西雅图Fred Hutchinson肿瘤研究中心的Marian Neuhouser和同事在《内科学文献》中发表，复合维生素的使用与肿瘤、心血管或死亡率预后风险的增加或降低没有明显地联系。
在调整多重变量后，复合维生素使用的危害比在乳腺癌是0.98、结肠直肠癌0.99、子宫内膜癌1.05、肺癌1.0、卵巢癌1.07、心血管疾病0.96、中风0.99、静脉血栓栓塞1.05、全因死亡率1.02。
Neuhouser和同事总结道，“这些结果表明对于绝经期后的女性，复合维生素的使用并不能对肿瘤或心血管疾病风险产生明显有益或有害的作用。”
营养补充仍应该作为慢性疾病预防的主要焦点，但是还没有一个确定的临床随机对照试验结果，复合维生素补充剂在这些疾病的预防方面将不可能起很大的作用。
Source:www.Incirculation.net
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Multivitamins fail to reduce cancer, CVD, death in older women
MedWire News: Multivitamins, the most commonly used dietary supplements, have no impact on the risk for cancer, cardiovascular disease, or mortality in postmenopausal women, a major study has found.
The research used data on 161,808 participants in the Women’s Health Study, 68,132 of whom were randomized to interventions (hormone therapy, dietary modification, and calcium/vitamin D supplements) and 93,676 of whom were simply observed.
Study enrolment occurred between 1993 and 1998 and the median duration of follow-up was 8.0 and 7.9 years in the intervention and observation arms, respectively. The overall prevalence of multivitamin use was 41.5%.
Multivitamin use was not associated with a significantly increased or decreased risk for any of the prespecified oncologic, vascular, or mortality outcomes, report Marian Neuhouser (Fred Hutchinson Cancer Research Center, Seattle, Washington, USA) and colleagues, writing in the Archives of Internal Medicine.
After adjustment for multiple variables, the hazard ratios associated with multivitamin use were 0.98 for breast cancer, 0.99 for colorectal cancer, 1.05 for endometrial cancer, 1.0 for lung cancer, 1.07 ovarian cancer, 0.96 for cardiovascular disease, 0.99 for stroke, 1.05 for venous thromboembolism, and 1.02 for all-cause mortality.
“These results suggest that multivitamin use does not confer meaningful benefit or harm in relation to cancer or cardiovascular disease risk in postmenopausal women,” Neuhouser and co-authors conclude.
“Nutritional efforts should remain a principal focus of chronic disease prevention, but without definitive results from a randomized controlled trial, multivitamin supplements will not likely play a major role in such prevention efforts.”
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