－－成人脂肪干细胞协同内皮干细胞有利于血管生成
Adipose stem cells show promise in preclinical cardiac work

　　国际脂肪治疗科学联合会主席Keith L. March医生对最近脂肪治疗科学联合会(IFATS)的医学研究会议做了总结报告，报告中指出成人脂肪干细胞促进血管新生，保护内皮祖细胞凋亡，在心血管领域有良好的应用前景。

　　March介绍，脂肪干细胞在已经完成的前期临床试验，与其它正在研究的有良好效果的几种细胞治疗药物以及到目前为止的临床研究比较，表明了其安全性和有效性。在临床前期研究中，在培养阶段，脂肪干细胞显示了高度的基因稳定性，在鼠和猪的皮肤全层损伤模型中，脂肪干细胞能明显加速伤口的愈合。它所释放的一种半固体状基质似乎对促进愈合至关重要。在动物模型中，脂肪干细胞表现出肝细胞样多功能的特性，他们也显示了一个能减少人源性肿瘤细胞生长的特点。

　　临床应用

　　脂肪干细胞已经在很多中心被用于人类美容和整形中。在(IFATS)医学研究会议中已经有100多个病例报道，其安全性和有效性得到了证明。脂肪干细胞应用的领域包括：完全或部分乳房切除，乳房造型，乳房增大术及骨愈合。

　　心血管领域的应用

　　在IFATS医学研究会议上几个研究小组报道的临床前研究数据支持脂肪干细胞有利于心肌缺血后组织的修复。

　　个体脂肪干细胞和内皮祖细胞相互协同的作用研究并且提供了证据是本研究的亮点，在试验中脂肪干细胞与内皮干细胞有很好的协同作用，促进血管新生并与宿主自身脉管系统有很好的相容性。试验中，脂肪干细胞还有抗内皮干细胞凋亡的作用，这种协同作用在血管稳定和组织新生方面发挥着重要作用。明年，我们还将报道来自亚洲和欧洲研究中心的相关安全数据。

　　（阜外心血管医院　陈俊 高立建　编译）

　　（医心网独家授权网站，转载请注明出自医心网）

Adipose stem cells show promise in preclinical cardiac work

Adult adipose stem cells appear to demonstrate synergy with endothelial progenitor cells in promoting vasculogenesis.

Adult adipose stem cells may be useful in vascular and cardiac applications, promoting robust vasculogenesis and protecting endothelial progenitor cells from apoptosis, according to Keith L. March, MD.

March, president of the International Federation of Adipose Therapeutics and Science (IFATS), presented a summary of the proceedings from the most recent IFATS medical and research conference.

Adipose stem cells have shown characteristics in preclinical work that compare favorably with several other cell-therapy agents under investigation, and clinical work with them to date has been characterized by safety and early efficacy, March said.

In preclinical investigations, adipose stem cells have displayed a high degree of genomic stability in culture over time, both within populations and in clones, March said. These stem cells have significantly accelerated wound healing in both mice and pig models of full-thickness wounds. Delivery of cells in a semisolid matrix seems to be important to successful outcomes, he said.

In animal models, adipose stem cells can express multiple functional properties of hepatocytes. They also have shown the ability to reduce the amount of growth of human-derived tumor cells.

Translating to clinic

Adipose stem cells have been used in numerous centers for cosmetic and reconstructive applications in humans, March said. Safety and early efficacy were consistently manifested in more than 100 patients described at the IFATS meeting, he said. Applications in which adipose stem cells have been used include complete and partial mastectomy, breast reconstruction, cosmetic breast augmentation, and bone healing.

The safety shown in these investigations to date provides “an important benchmark for this field as it advances into humans,” March said.

Cardiac, vascular applications

Several groups at the IFATS meeting reported preclinical data supporting the ability of adipose stem cells to repair postischemic myocardial tissue, March said.

Of particular interest is evidence of cooperation between two human stem cell types, adipose stem cells and endothelial progenitor cells. In a chimeric adult human host, these cell types in combination demonstrate an apparent synergy, causing robust vasculogenesis and integration with host vasculature. It appears that the adipose stem cells provide an antiapoptotic effect on the endothelial progenitor cells, March said. The synergy may play a role in vascular stability as well as tissue generation, he said.

Next year, early human cardiovascular safety data will be reported from a number of centers in Europe and Asia, March said.