Do Drug-eluting Stents Decrease Mortality?

　　来自真实世界的注册研究资料显示DES一直是安全有效的。

　　TCT2007大会发布了DES能够安全地改善患者预后，并且能够在一些病例中减少死亡率的报告。

　　CRF主席Gregg Stone医生在主持会议时说：“这些证明DES持续安全有效的数据十分鼓舞人心，目前的挑战是如何将这些从不同领域得到的数据整合在一起，并应用于临床实践中。”

　　除此之外，Stone医生在会议上还展示了TAXUS注册研究具有划时代意义的结果，这一研究观察了长期服用氯吡格雷对死亡、心梗和支架血栓的影响。研究结果显示在接受DES或金属裸支架治疗后无事件的单支原发自身冠脉病变的患者中，不支持常规延长至1年以上噻氯吡啶类药物治疗。

　　新泽西医科和齿科大学的心脏病学家Tudor D. Vagaonescu医生同时在会议上展示了MIDAS注册研究的结果。该研究在2003至2004年共入选了11118例接受单个BMS（n=5399）和单个DES（n=5719）的患者。

　　Vagaonescu医生公布的研究结果显示在急性心肌梗死（AMI）患者中，与BMS相比置入单个DES能够明显减少两年的全因死亡率和心血管死亡率。

　　（首都医科大学附属北京安贞医院　苑飞　编译）

　　（医心网独家授权资料，转载请注明出处）

Do Drug-eluting Stents Decrease Mortality?

Registry data from real-world practice with DES are showing consistently positive safety, efficacy data.
 
According to reports presented atTCT 2007, DES have improved outcomes and done so safely, in some cases reducing mortality.

“It is encouraging that these data so consistently show safety and efficacy. The challenge will be synthesizing the data from so many different areas into information for clinical practice,” Gregg Stone, MD, Chairman of the Cardiovascular Research Foundation, said during the session.

In addition to moderating, Stone presented landmark results of the TAXUS registry concerning the impact of longterm clopidogrel use on death, MI and stent thrombosis. The data do not support routinely extending thienopyridine treatment beyond one year in patients who were event-free after either treatment with DES or bare-metal stents in single, de novo lesions in native coronary arteries.

Tudor D. Vagaonescu, MD, a cardiologist at the University of Medicine and Dentistry of New Jersey, presented MIDAS registry data on 11,118 patients who were treated with either a single baremetal stent (n = 5,399) or a single DES  (n = 5,719) in the years 2003 and 2004.

Vagaonescu concluded that the use of a single DES in the setting of AMI was associated with a significant reduction of two-year all-cause mortality and cardiovascular mortality when compared with the use of a single bare-metal stent.