Recurrence of Atrial Fibrillation Reduced With Alpha-Linolenic Acid-Enriched Diet: Presented at DALM

　　2007年10月17日Lanzmann-Petithory MD在纽约的第16届国际药物对血脂代谢影响的研讨会（DALM）上提出α亚麻酸（ALA）可以降低房颤的复发率。

　　来自法国巴黎Emile Roux医院老年医学科的Lanzmann-Petithory MD等的随机研究共纳入111例房颤患者。其中53例患者用富含α亚麻酸的坎诺拉植物黄油和坎诺拉食用油（每天1.4g ω-3亚麻酸ALA）代替原先的高脂肪饮食，45例患者继续日常饮食。

　　于2个月，6个月和12个月时收集所用入选患者空腹血及24小时饮食问卷，或直到房颤复发。分析ALA组40例（平均BMI28 ± 4.7 kg/m2）和对照组35例患者（平均BMI27.4 ± 4.1 kg/m2）的资料发现短链的ω-3脂肪酸可以降低房颤的复发率。1年的Kaplan-Meier生存曲线分析发现ALA组的房颤复发率明显降低（OR 2.15，P =0.037）。对照组和ALA组的12个月内无房颤生存率分别为25.52% 和63.09%。

　　目前的初步研究结果支持进一步探讨应用ALA降低心血管危险。研究者认为，西部人群的ALA摄入水平明显低于1.5 g/d（男性）和1.3 g/d（女性），该研究结果尤其适于此类人群的患者。

　　心律失常和室颤是心梗后心源性猝死的常见原因。研究者已着手应用营养途径预防威胁生命的心律失常事件的研究。特别是在Lyon Diet Heart研究证实ALA可降低致命性和非致命性心脏事件的发生率。该研究在波尔多葡萄酒产区三所大学的医院启动。

　　（来源：www.docguide.com）

Recurrence of Atrial Fibrillation Reduced With Alpha-Linolenic Acid-Enriched Diet: Presented at DALM

By Crina Frincu-Mallos, PhD

NEW YORK, NY -- October 17, 2007 -- Alpha-linolenic acid (ALA) may reduce the recurrence of atrial fibrillation, according to researchers reporting at the XVI International Symposium on Drugs Affecting Lipid Metabolism (DALM).

Dominique Lanzmann-Petithory, MD, PhD, Physician Practitioner in Public Health, Department of Geriatric Medicine, Emile Roux Hospital, Paris, France, and colleagues randomised a total of 111 patients in a controlled efficacy study. Fifty-three patients were started on an ALA-rich diet in which they were instructed to replace any other fats and oils with canola margarine and canola oil (1.4 g/day ALA omega 3 fatty acid). Forty-five patients continued to eat their usual diet.

Fasting blood samples and 24-hour dietary recalls were collected at enrollment, and at 2, 6 and 12 months, or until the recurrence of atrial fibrillation.

Data from 40 patients in the ALA group (mean BMI 28+- 4.7 kg/m2) and 35 control patients (mean BMI 27.4+- 4.1 kg/m2) demonstrate that the shorter chain omega-3 vegetable fatty-acid ALA may reduce the recurrence of atrial fibrillation, noted Dr. Lanzmann-Petithory.

The Kaplan-Meier Survival curves for atrial-fibrillation recurrence during the year demonstrated that recurrence was significantly less prone to occur in patients on the ALA treatment (OR 2.15, P =.037). The survival rate was 25.52% in the control group versus 63.09% in the ALA group at the end of the 12-month period.

"The present preliminary study provides support for further exploration of the use of ALA in the reduction of cardiovascular risk," said the researchers.

Since the levels of ALA intake in Western populations are much lower than the advised 1.5 g/day (for men) and 1.3 g/day (for women), these results are particularly relevant for this patient population, the researchers concluded.

Cardiac arrhythmia and ventricular fibrillation are usually responsible for sudden cardiac death following an infarction, and the prevention of life-threatening arrhythmic events is a problem researchers have already started to tackle using a nutritional approach -- especially after the Lyon Diet Heart Study demonstrated that ALA reduced fatal and non-fatal cardiac events.

This study took place at three university hospital centers in the Bordeaux region of France.

[Presentation title: Prevention of Atrial Fibrillation Recurrence With an alpha-Linolenic Acid-Enriched Diet: A Randomized Study. Abstract 439]